Figure 3.

Histology of lungs isolated from compound SP-B mice following gene transfer and removal of doxycycline. The left lobes of the mouse lungs were inflation fixed with 4% paraformaldehyde and then paraffin-embedded for thin sectioning. Eight micron sections were de-paraffinized and stained with hematoxylin and eosin. Representative sections from three different mice are shown for each condition. Compound SP-B transgenic mice maintained on a doxycycline diet that received no additional treatment and those that received a diet containing no doxycycline for 4 days without DNA electroporation are also shown for comparison.