Figure 4.

Lung myeloperoxidase activity in compound SP-B mice following gene transfer and removal of doxycycline. Compound SP-B transgenic mice (n = 5) were either maintained on doxycycline or were taken off doxycycline and 100 µg of each plasmid (or no DNA) was delivered to the lungs by electroporation as in Figure 1. Four days later, lungs were removed from animals and portions were homogenized for quantitation of myeloperoxidase activity and normalized to total cell protein (mean ± st. dev.)