TABLE 2.
Stable IPF | Acute exacerbation of IPF |
p-value | |
---|---|---|---|
Subjects n | 30 | 24 | |
Radiological features | |||
Hiatal hernia prevalence | 57% (17) | 67% (16) | 0.45 |
Hiatal hernia diameter cm | 1.4 (0–1.5) | 1.5 (0–1.6) | 0.39 |
Hiatal hernia height cm | 1.0 (0–2.0) | 2.0 (0–2.5) | 0.29 |
Ground-glass opacity score % | 2 (0–5) | 18 (6–27) | <0.01 |
Consolidation score % | 0 (0–0) | 0 (0–3) | <0.01 |
Honeycombing score % | 4 (1–9) | 6 (3–12) | 0.17 |
Reticulation score % | 6 (3–8) | 9 (5–27) | <0.01 |
Overall CT score % | 13 (8–23) | 43 (26–63) | <0.01 |
BAL fluid features | |||
Pepsin concentration ng·mL−1 | 35.4 (14.5–55.6) | 46.8 (18.9–92.0) | 0.15 |
Total cell count cells·mL−1 | 254 (140–380) | 270 (150–380) | 0.84 |
Neutrophils | |||
% | 6 (2–10) | 13 (6–28) | 0.02 |
Cells·mL−1 | 11 (6–23) | 25 (8–63) | |
Lymphocytes | |||
% | 10 (7–18) | 17 (6–32) | 0.25 |
Cells·mL−1 | 23 (11–70) | 26 (8–70) | |
Alveolar macrophages | |||
% | 73 (60–88) | 52 (30–64) | <0.01 |
Cells·mL−1 | 176 (97–294) | 134 (39–195) | |
Eosinophils | |||
% | 4 (1–9) | 2 (0–7) | 0.16 |
Cells·mL−1 | 7 (2–28) | 5 (0–18) | |
Red blood cell count cells·mL−1 | 65 (10–230) | 500 (180–1500) | <0.01 |
Data are presented as % (n) or median (interquartile range), unless otherwise stated. IPF: idiopathic pulmonary fibrosis; CT: computed tomography.
: at the time of bronchoalveolar lavage.