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. 2017 May 24;13(7):1252–1253. doi: 10.1080/15548627.2017.1319041

Figure 1.

Figure 1.

A model of autophagosome maturation in wild-type and ATG conjugation-deficient cells. (1) Scission between the IAM and OAM in an ATG conjugation-dependent manner. (2) An oblate-to-spherical morphological change of the autophagosome and STX17 recruitment (immediately before or after closure). (3) Fusion of lysosomes with the OAM and introduction of lysosomal enzymes into the space between the OAM and IAM. (4) Degradation of the IAM. The steps that are affected in ATG conjugation-deficient cells are indicated.