Table 1.
Demographic, clinical, and laboratory characteristics of orthogeriatric patients by fracture status
| Variables | Total (n=1,239) | HF (n=455) | Non-HF (n=399) | No fracture (n=385) |
|---|---|---|---|---|
| Age, years | 78.1±9.52 | 83.0±8.48c,f | 76.6±9.49c | 73.9±8.06 |
| Females, n (%) | 855 (69.1) | 331 (73.2)c | 292 (72.8)c | 232 (60.6) |
| RCF resident, n (%) | 190 (15.4) | 126 (27.7)c,f | 42 (10.5)a | 22 (5.7) |
| Osteoporosis, n (%) | 239 (19.3) | 120 (26.4)c,e | 73 (18.3)a | 46 (12.0) |
| Dementia, n (%) | 178 (14.4) | 125 (27.5)c,f | 33 (8.3) | 20 (5.2) |
| P1NP, µg/L | 58.7±89.3 | 56.5±101.6 | 58.0±71.2 | 62.0±90.8 |
| OC, ng/mL | 6.8±4.7 | 6.5±4.8 | 7.1±4.6 | 6.9±4.7 |
| βCTX, µg/L | 0.50±0.35 | 0.56±0.36c,e | 0.49±0.36a | 0.43±0.32 |
| P1NP/βCTX | 123.3±101.9 | 103.4±93.9c,f | 127.1±83.8b | 147.2±104.9 |
| OC/βCTX | 16.2±11.1 | 13.6±9.4c,f | 18.1±12.5 | 19.4±12.2 |
| 25(OH)D, nmol/L | 62.9±26.3 | 61.6±27.6 | 64.8±26.5 | 62.4±24 |
| <25 nmol/L, n (%) | 96 (7.8) | 49 (10.8)a,e | 22 (5.6) | 25 (6.7) |
| <50 nmol/L, n (%) | 394 (31.9) | 155 (34.1) | 122 (30.8) | 117 (31.2) |
| PTH, pmol/L | 7.4±5.36 | 8.1±5.99c,e | 7.0±4.96 | 6.8±4.84 |
| >6.8 pmol/L, n (%) | 472 (38.2) | 206 (45.6)c,d | 147 (37.3)a | 119 (31.5) |
| Calcium,* mmol/L | 2.41±0.13 | 2.39±0.14c,d | 2.41±0.13b | 2.43±0.13 |
| Phosphate, mmol/L | 0.91±0.25 | 0.87±0.24c,f | 0.93±0.25 | 0.94±0.24 |
| Magnesium, mmol/L | 0.76±0.10 | 0.74±0.10c,f | 0.78±0.09 | 0.77±0.10 |
| Albumin, g/L | 32.1±4.41 | 30.2±3.90c,f | 32.8±4.29 | 33.5±4.35 |
| <33 g/L, n (%) | 688 (55.6) | 342 (75.2)c,f | 185 (46.4) | 161 (42.2) |
| Hemoglobin, g/L | 109.5±17.9 | 104.8±17.2c,f | 112.5±17.6 | 118.1±17.9 |
| <120 g/L, n (%) | 876 (70.8) | 366 (80.4)c,f | 254 (63.7) | 256 (66.8) |
| GFR, mL/min/1.73 m2 | 72.6±18.9 | 70.7±19.8e | 74.7±17.4 | 72.5±19.0 |
Notes: Data expressed as mean ± SD or number (percentage). Comparison with no fracture group:
P<0.05,
P<0.01, and
P<0.001. Comparison patients with hip fracture and other nonvertebral fractures:
P<0.05,
P<0.01, and
P<0.001.
Calcium corrected for albumin. Of note, the proportion of patients with hypertension, chronic heart failure (CHF), diabetes mellitus (DM), chronic obstructive airway disease (COPD), chronic kidney disease (CKD, GFR <60 mL/min/1.73 m2), history of malignancy, as well as current smokers and warfarin users were similar in the three groups; the mean serum levels of alkaline phosphatase (ALP), thyroid-stimulating hormone (TSH), and free thyroxine (fT4) did not differ between the three groups (data not shown).
Abbreviations: βCTX, β C-terminal βcross-linked telopeptide of type I collagen; HF, hip fracture; OC, osteocalcin; P1NP, N-terminal propeptide of type I procollagen; PTH, parathyroid hormone; RCF, residential care facility.