Table 3.
Bone turnover markers and hypoalbuminemia as indicators of nonvertebral osteoporotic fractures in orthogeriatric patients
| Variables | OR (95% CI) | AUC | Sensitivity, % | Specificity, % | PPV, % | NPV, % | Accuracy, % |
|---|---|---|---|---|---|---|---|
| Hip fracture | |||||||
| P1NP/βCTX <100 | 2.8 (2.0; 3.8)a | 0.802 | 78.5 | 68.9 | 75.2 | 72.8 | 74.1 |
| P1NP <62.0 µg/L | 1.7 (1.2; 2.4)b | 0.785 | 76.3 | 65.2 | 72.3 | 69.8 | 71.2 |
| βCTX >0.250 µg/L | 1.3 (0.9; 1.9)c | 0.781 | 77.0 | 65.5 | 72.9 | 70.4 | 71.8 |
| Albumin <33 g/L | 3.1 (2.2; 4.3)a | 0.806 | 78.7 | 71.5 | 76.7 | 73.8 | 75.4 |
| P1NP/βCTX <100 + albumin <33 g/L | 7.8 (4.9–12.4)a | 0.855 | 83.0 | 75.6 | 80.4 | 78.7 | 79.6 |
| Any fracture | |||||||
| P1NP/βCTX <100 | 2.1 (1.6; 2.8)a | 0.711 | 90.1 | 27.1 | 73.5 | 54.8 | 70.7 |
| P1NP <62.0 µg/L | 1.5 (1.1; 2.0)b | 0.695 | 90.3 | 18.7 | 71.3 | 46.4 | 68.2 |
| βCTX >0.250 µg/L | 1.2 (0.9; 1.6)c | 0.691 | 91.3 | 17.2 | 71.3 | 46.8 | 68.5 |
| Albumin <33 g/L | 2.2 (1.3; 2.7)a | 0.706 | 89.3 | 19.9 | 71.4 | 45.5 | 67.9 |
| P1NP/βCTX <100 + albumin <33 g/L | 3.2 (2.2–4.6)a | 0.754 | 85.7 | 41.8 | 75.7 | 58.0 | 71.6 |
Notes: Data adjusted for age and gender;
a
P<0.001;
b
P<0.01;
c
P>0.200.
Abbreviations: P1NP, N-terminal propeptide of type 1 procollagen; βCTX, cross-linked carboxy-terminal telopeptide of type 1 collagen; OR, odds ratio; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.