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. 2017 Jul 14;10:1645–1655. doi: 10.2147/JPR.S135017

Figure 1.

Figure 1

ALA attenuated colonic hypersensitivity in rats with diabetes.

Notes: (A) ALA at 30, 60, and 120 mg/kg resulted in a dramatic increase in the DT to CRD, and NS had no significant effect on the DT (n=6 for each group, **p<0.01, compared with Pre, two-way repeated-measures ANOVA followed by Tukey post hoc test). (B) Time course of ALA-induced analgesic effect. ALA at 60 mg/kg significantly increased the DT at 2 hours, which lasted for ~24 hours (n=6 for each group, *p<0.05, compared with Pre, one-way repeated-measures ANOVA followed by Tukey post hoc test). (C) ALA at 60 mg/kg had no significant effect on the DT in age- and sex-matched healthy CON rats. (n=6 for each group, p>0.05, compared with Pre, two-sample t-test). (D) ALA at 60 mg/kg did not affect motion on Rotarod of diabetic rats. (n=6, p>0.05, compared with Pre, paired-sample t-test).

Abbreviations: ALA, α-lipoic acid; ANOVA, analysis of variance; CON, control; CRD, colorectal distension; DT, distention threshold; NS, normal saline.