Figure 5.

ALA decreased sodium current densities of DRG neurons.

Notes: (A) Examples of voltage-gated sodium currents recorded from NS- (left) and ALA-treated rats (right). Membrane potential was held at −60 mV and voltage steps were from −70 to +50 mV with 10 mV increments and 80 ms duration. (B) I–V curves for sodium currents of colon DRG neurons from NS- (n=10) and ALA-treated rats (n=13). (C) Bar graph showing the mean peak sodium current densities. ALA treatment significantly reduced the peak sodium currents densities (**p<0.01, compared with NS, Mann–Whitney test).

Abbreviations: ALA, α-lipoic acid; DRG, dorsal root ganglion; I–V, current–voltage; NS, normal saline.