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. 2017 Jul 14;10:1645–1655. doi: 10.2147/JPR.S135017

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© 2017 Sun et al. This work is published and licensed by Dove Medical Press Limited

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ALA downregulated NaV1.7 and NaV1.8 expression.

Notes: (A) Western blots for NaV1.7 of T13-L2 DRGs from NS- and ALA-treatment rats. Bar graph showed mean density relative to GAPHD for NaV1.7. ALA treatment greatly reduced expressions of NaV1.7 (n=4 for each group, **p<0.01, compared with NS, two-sample t-test). (B) Western blots for NaV1.8 of T13-L2 DRGs from NS- and ALA-treatment rats. Bar graph showed mean density relative to β-actin for NaV1.8. ALA treatment greatly reduced expressions of NaV1.8 (n=5 for NS group, n=4 for ALA group, *p<0.05, compared with NS, two-sample t-test).

Abbreviations: ALA, α-lipoic acid; DRG, dorsal root ganglion; NS, normal saline.