Table 1.
Changes of membrane properties of colonic DRG neurons after ALA treatment
| Parameters | STZ+NS | STZ+ALA | p-value |
|---|---|---|---|
| Cell Size (μm) | 25.7±0.6 (n=24) | 25.8±0.6 (n=24) | 0.907 |
| Cm (pF) | 23.8±1.1 (n=24) | 26.8±1.7 (n=24) | 0.139 |
| Rin (MΩ) | 615.3±48.0 (n=24) | 519.3±42.8 (n=24) | 0.711 |
| AP Amplitude (mV) | 85.3±1.9 (n=24) | 86.0±2.6 (n=24) | 0.837 |
| AP Overshoot (mV) | 41.2±1.2(n=24) | 42.1±1.8 (n=24) | 0.682 |
| AP Duration (ms) | 2.6±0.2 (n=24) | 2.6±0.2 (n=24) | 0.975 |
| Latency (ms) | 125.3±23.1 (n=24) | 129.1±20.6 (n=24) | 0.975 |
Notes: Values are mean ± SEM, with sample size in parenthesis. P-values were determined by two-sample t-test or Mann–Whitney test.
Abbreviations: ALA, α-lipoic acid; AP, action potential; Cm, membrane capacitance; DRG, dorsal root ganglion; NS, normal saline; Rin, input resistance; STZ, streptozoin.