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. Author manuscript; available in PMC: 2017 Jul 26.
Published in final edited form as: J Med Chem. 2016 Apr 11;59(8):4019–4025. doi: 10.1021/acs.jmedchem.5b01536

Figure 1.

Figure 1

Evolution of CAV ligands. Sequence alignment showing the progression of peptide ligands from the native gp41 segment sequence (2) to T20 (3), to ligands 4, 5, and 6, and ultimately to ligand 1, which binds CAV(1-104) with 7500-fold higher affinity despite an 80% decrease in length compared to 3. Residues mutated from 3 are in red. Numbers above 2 indicate the residue numbers from the original protein.