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. Author manuscript; available in PMC: 2017 Jul 26.
Published in final edited form as: J Med Chem. 2016 Apr 11;59(8):4019–4025. doi: 10.1021/acs.jmedchem.5b01536

Figure 7.

Figure 7

Disruption of oligomers. a) CAV(FLV) spontaneously forms oligomers which can be measured by dynamic light scattering (DLS). In this experiment, these oligomers had an apparent average diameter near 90 nm with polydispersity (indicated in teal) corresponding to approximately a 55 nm range. Incubating these oligomers with ligand 1 resulted in reduced average diameter and increased polydispersity, which are the expected outcomes of deoligomerization. With the disulfide dimerization of the ligand disrupted by reducing conditions, no deoligomerization effect was observed. b) In a separate DLS experiment, CAV(FLV) oligomeric peaks at 32 nm (blue, left axis) and 240 nm (green, right axis) each showed a dose-dependent reduction in diameter when incubated with varied concentrations of ligand 1. A maximum size reduction of 30% and 40% was observed for the respective peaks.