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. Author manuscript; available in PMC: 2017 Jul 26.
Published in final edited form as: Nat Rev Clin Oncol. 2016 Mar 22;13(6):370–383. doi: 10.1038/nrclinonc.2016.36

Figure 1. CAR-T-cell design.

Figure 1

All chimeric antigen receptor (CAR) designs contain an antigen-recognition domain and a signalling domain that provides ‘signal 1’ to activate T cells. Only this signalling domain is present in first-generation CARs. By contrast, a co-stimulatory signalling domain that provides ‘signal 2’ is added in second-generation CARs, and in third-generation CARs two co-stimulatory signalling domains are added.