Figure 8. PCA-based evaluation of MRI biomarkers.
(A) Correlation matrix of imaging parameters used for PCA. Only data of kainate-injected mice was analyzed. Positive and negative correlation coefficients are color-coded in red and blue, respectively. (B) Pearson’s correlation analysis of PC1 scores and total GCL volume, (C) extent of microgliosis and (D) radial gliosis (i.e optical density of GFAP in the GCL) in epileptic mice (color-coded, n = 7). Controls (grey, n = 5) are plotted but not included in the analysis. (E) Correlation plot showing the similarity of individual MRI variables with PC1 and 2. Clusters of variables, indicated as numbers, are grey scale-coded. Arrows denote the population vector of the corresponding cluster. Coefficients are indicated as circles (small = 0.5; large = 1.0).