Table 1. Subjects.
| SAGE subjects
|
RT-PCR confirmation subjects
|
||||||
|---|---|---|---|---|---|---|---|
| P1 | P2 | C1 | A1 | A2 | Controls (n = 19) | Patients (n = 25) | |
| Age, yr | 71 | 72 | 68 | 45 | 39 | 70 ± 5 | 74 ± 8 |
| Gender | M | F | F | M | M | 42% male | 60% male |
| Systolic blood pressure, mm Hg | 134 | 120 | 145 | 130 | 115 | 141 ± 18 | 143 ± 20 |
| LDL, mg/dl | 101 | 100 | 65 | 87 | 124 | 110 ± 33 | 103 ± 28 |
| HDL, mg/dl | 44 | 66 | 48 | 55 | 47 | 56 ± 21 | 53 ± 16 |
| Diabetes mellitus | – | – | – | – | – | 5% | 8% |
| Current smoker | – | – | – | – | – | 0% | 4% |
| Family history of CHD | – | + | – | – | – | 36% | 48% |
| History of CHD | + | + | – | – | – | 0% | 56% |
| Body mass index, kg/m2 | 29.2 | 27.7 | 28.0 | 25.6 | 23.0 | 26.3 ± 3.8 | 26.4 ± 4.9 |
| Framingham 10-yr CHD risk, % | 18 | 8 | 9 | 3 | 3 | 13 ± 9 | 15 ± 10 |
Individual profiles of the subjects used for SAGE library construction and group profiles of normal subjects (Controls) and CEA patients with atherosclerosis (Patients) used for quantitative RT-PCR. Subjects with atherosclerosis: P1, patient 1; P2, patient 2. Subjects without clinically significant atherosclerosis: C1, age-matched control 1; A1, younger age control 1; A2, younger age control 2. CHD, coronary heart disease.