Skip to main content
. Author manuscript; available in PMC: 2018 Jun 23.
Published in final edited form as: Neuroscience. 2017 Apr 19;354:88–100. doi: 10.1016/j.neuroscience.2017.04.009

Figure 1.

Figure 1

Alcohol consumption in non-dependent and alcohol dependent CCL2-tg and non-tg mice. (A) In non-dependent CCL2-tg and non-tg mice subjected to the 2BC drinking paradigm, females drank more than males but comparable increases in alcohol consumption were observed for CCL2-tg and non-tg mice of the same sex during the periods of 24 hr access to escalating concentrations of alcohol. (B) During the period of limited access, a small reduction in mean alcohol consumption (data from males and females combined) was observed in the CCL2-tg mice compared to non-tg mice. (C) In CCL2-tg and non-tg mice made alcohol dependent by the CIE/2BC paradigm, alcohol consumption was significantly increased in the non-tg mice but not in the CCL2-tg mice. Numbers in bars are number of mice tested. *significant genotypic difference. @significantly different from baseline values for the same group and genotype.