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. Author manuscript; available in PMC: 2018 Jun 23.
Published in final edited form as: Neuroscience. 2017 Apr 19;354:88–100. doi: 10.1016/j.neuroscience.2017.04.009

Figure 2.

Figure 2

Alcohol-induced impairments in spatial learning in non-dependent CCL2-tg mice. (A–C) Non-dependent CCL2-tg mice subjected to the 2BC drinking paradigm showed impairments in spatial learning and memory in the Barnes maze test compared with the alcohol naïve CCL2-tg mice. Data were averaged over 3 day periods. During the first time period (1–3 d) non-dependent CCL2-tg mice had increased latency (A), errors to escape (B) and spent less time in the target quadrant (C). Non-dependent and alcohol naïve non-tg mice exposed to the same paradigms did not show impairments. *significant genotypic difference for the same group. # significant group difference for the same genotype.