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(A) Dynamic change of APN in high-fat–high-glucose diet-induced T2DM model in rats (n=23 rats/group). (B) APN level in different groups at the end of 32 weeks (n=11–12 rats/group). *P<0.05, **P<0.01 vs. normal diet group; ##P<0.01 vs. T2DM group.
