Table 3.
Diabetes management and other outcomes at baseline, 3, 6 and 12 months
| TEDDY (N=37) baseline | Community (N=35) baseline | Mean Diff (95% CI)ˆ | TEDDY (N=43) 3 month | Community (N=40) 3 month | Mean Diff (95% CI)ˆ | TEDDY (N=42) 6 month | Community (N=38) 6 month | Mean Diff (95%CI)ˆ | TEDDY (N=36) 12 month | Community (N=27) 12 month | Mean Diff (95% CI)ˆ | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HbA1c*, % (mmol/mol) | 6.3±0.9 45+10 |
7.7±1.0 61+11 |
−1.4 −1.9, −0.8) −15 (−21, −9) |
6.7±1.0 50+11 |
7.1±0.9 54+10 |
−0.4 (−0.9, 0.1) −5 (−10, 1) |
7.0±1.1 53+12 |
7.5±1.1 58+12 |
−0.2 (−0.7, 0.4) −2 (−8, 4) |
7.1±0.9 54+10 |
7.8±1.2 62+13 |
−0.5 (−1.1, 0.1) −6 (−12, 1) |
| BG† tests/day* | 5.6±2.2 | 6.9±2.9 | −0.6 (−2.3, 1.2) |
6.1±2.4 | 6.3±2.5 | −0.1 (−1.1, 0.9) |
6.3±2.1 | 6.3±3.0 | −0.1 (−1.2, 1.1) |
6.6±2.2 | 6.2±2.6 | 0.6 (−0.7, 2.0) |
| ≤2 inj/≥3 inj/pump, N(%)‡ | 13/15/0 (46/54/0) |
0/35/0 (0/100/0) |
– | 13/28/1 (31/67/2) |
2/35/3 (5/88/7) |
– | 8/30/4 (20/71/9) |
1/30/7 (3/79/18) |
– | 6/23/6 (17/66/17) |
0/17/10 (0/63/37) |
– |
| Insulin dose* (u/kg/d) | 0.3+0.2 | 0.4+0.2 | −0.2 (−0.3, −0.1) |
0.3+0.3 | 0.5+0.3 | −0.2 (−0.3, −0.1) |
0.4+0.3 | 0.6+0.2 | −0.2 (−0.3, −0.1) |
0.5+0.3 | 0.7+0.3 | −0.2 (−0.4, −0.0) |
| Short acting* (u/kg/d) | 0.2±0.2 | 0.2±0.1 | −0.1 (−0.2, 0.0) |
0.2±0.2 | 0.3±0.2 | −0.1 (−0.2, −0.0) |
0.2±0.2 | 0.3±0.2 | −0.1 (−0.2, −0.0) |
0.3±0.2 | 0.4±0.2 | −0.1 (−0.3, −0.0) |
| Long acting*(u/kg/d) | 0.1±0.1 | 0.2±0.1 | −0.1 (−0.1, −0.0) |
0.1±0.1 | 0.2±0.1 | −0.1 (−0.1, −0.0) |
0.2±0.1 | 0.3±0.1 | −0.1 (−0.2, −0.1) |
0.2±0.1 | 0.3±0.1 | −0.1 (−0.2, 0.0) |
| IDAA1C*,§ | 7.6±1.8 | 9.4±1.1 | −1.8 (−2.9, −0.8) |
7.9±1.7 | 9.0±1.5 | −1.1 (−1.8, −0.3) |
8.5±1.7 | 9.7±1.5 | −0.8 (−1.6, 0.0) |
9.1±1.6 | 10.7±1.8 | −1.3 (−2.4, −0.2) |
Mean ± standard deviation are shown unless specified otherwise
missing information in some subjects
BG: blood glucose
inj: injections
IDAA1C: Insulin-dose adjusted A1c: calculated as A1c (%) + [4 × insulin dose (units/kg/day)]
Mean Diff (95% CI): mean difference (95% confidence intervals)