Table 3.

Baseline chondrocalcinosis and knee pain (continuous measurement) at year 0 and year 4, and change of knee pain

CC at baseline	Crude model		Adjusted model*
	mean (95% CI)	p-value	adjusted mean (95% CI)	p-value
knee pain severity, past 30 days (0–10)
at year 0
CC− (n=2026)	2.3 (2.2,2.4)	0.04	2.0 (1.9,2.2)	0.02
CC+ (n=162)	2.8 (2.3,3.3)		2.6 (2.2,3.1)
at year 4
CC− (n=1895)	2.2 (2.1,2.4)	0.19	2.0 (1.8,2.1)	0.11
CC+ (n=151)	2.6 (2.1,3.1)		2.4 (1.9,2.9)
change from year 0 to year 4
CC− (n=1891)	0.0 (−0.2,0.1)	0.47	−0.1 (−0.2,0.1)	0.50
CC+ (n=151)	−0.3 (−0.8,0.3)		−0.3 (−0.9,0.3)
WOMAC knee pain subscale (0–20)
at year 0
CC− (n=2030)	2.1 (1.9,2.2)	0.08	1.8 (1.7,1.9)	0.03
CC+ (n=162)	2.6 (2.0,3.1)		2.4 (1.9,2.9)
at year 4
CC− (n=1898)	1.8 (1.7,2.0)	0.01	1.6 (1.5,1.8)	<0.01
CC+ (n=151)	2.6 (2.0,3.2)		2.5 (1.9,3.1)
change from year 0 to year 4
CC− (n=1898)	−0.2 (−0.3,0.0)	0.63	−0.1 (−0.3,0.0)	0.68
CC+ (n=151)	0.0 (−0.7,0.6)		0.0 (−0.6,0.6)

^*Adjusting for age, gender, BMI, and KL grade at baseline