Figure 3c:

MR elastography results and histologic analyses in the CCl₄ mouse model. (a) Chart shows necroinflammation and fibrosis extent in the livers of mice with disease and CCl₄ administration. All control animals had normal histologic findings. (b, c) MR elastography results of liver stiffness (b) and damping ratio (c) at 200 Hz. Paired t tests were performed to compare CCl₄ mice and age-matched control animals at 1, 2, 4, and 6 weeks of administration. (The number of animals was 3:3 for each comparison.) Shear stiffness (b) and damping ratio (c) showed that the liver stiffness increased gradually with the CCl₄ exposure time and could be used to detect significant fibrosis at weeks 4 and 6. Early liver injury could be distinguished with only the significantly increased damping ratio in the treatment group.