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. Author manuscript; available in PMC: 2017 Jul 27.
Published in final edited form as: Leukemia. 2016 Dec 28;31(8):1798–1807. doi: 10.1038/leu.2016.392

Figure 6. Overexpression of GIMAP genes accelerates T-ALL onset in vivo.

Figure 6

(A) Tumor development in transgenic zebrafish. Tumor cells expressing fluorescent proteins (eGFP and mCherry) in rag2::Myc-EGFP; rag2::mCherry (MYC) (n=15) and rag2::Myc-EGFP; rag2::hGIMAP5; rag2::hGIMAP7; rag2::mCherry (MYC; hGIMAP5,7) (n=9) transgenic fish were analyzed at 4 and 6 weeks using epi-fluorescence stereomicroscopy. Two representative zebrafish for each group are shown. Panels show the merged fluorescent and bright-field images. Scale bar, 5 mm. (B) The tumor onset of T-ALL in MYC-transgenic fish (n=15) and MYC; GIMAP5, 7 transgenic fish (n=9) were analyzed via the Kaplan-Meier method. P<0.05 by the Gehan-Breslow-Wilcoxon test.