Table 2.

Endpoints.

Primary endpoint

Composite of stroke (ischemic/hemorrhagic)/transient ischemic attack and systemic embolism

Secondary endpoint

Major bleeding (ISTH criteria)

Non-major and clinically relevant bleeding

Composite of symptomatic stroke (ischemic/ hemorrhagic), systemic embolism, myocardial infarction and/or cardiovascular death

Symptomatic ischemic stroke

Symptomatic hemorrhagic stroke

Systemic embolism

Acute myocardial infarction/ unstable angina, CABG/PCI, or cardiovascular death

Transient ischemic attack

All-cause death

Adherence of medication: the annual prescription rate is calculated by dividing the annual number of tablets prescribed by 365 days. (The physician reports the annual number of tablets in Case Report Form.)

The rivaroxaban prescription status will be reported by the physician in each data collection timing.

ISTH: International Society on Thrombosis and Hemostasis.

CABG: Coronary Artery bypass grafting.

PCI: Peripheral Component Interconnect.