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UA treatment prevents the histological damage normally associated with SCI. Adult CD1 mice were subjected to compression-induced SCI and treated with UA or saline as detailed in the legend to Fig. 2. Spinal cord biopsies were collected 24 h after SCI, and sections from sham-operated (a), saline-treated (b and b1), and UA-treated (c) SCI mice were stained with hematoxylin/eosin as described in Materials and Methods and photographed (a, b, and c, ×200; b1, ×450).
