Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 27;11:226. doi: 10.3389/fncel.2017.00226

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Koroleva, Mustafina, Yakovlev, Hermann, Giniatullin and Sitdikova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Facilitatory and inhibitory effects of NaHS on capsaicin induced currents in rat TG neurons. (A,B) Representative traces of capsaicin evoked currents (Caps, 1 μM, 2 s, short bars above traces) in control and during bath application of 100 μM NaHS for 15 min (solid bar above traces). Capsaicin was applied at an interval of 5 min to prevent desensitization of TRPV1 receptors. (C,D) Average amplitude of TRPV1 currents in control (three subsequent capsaicin application) and during NaHS application (solid bars above traces). Notice the increase of mean amplitude of TRPV1 currents after 5 min of NaHS perfusion in (C) and the constant decrease of capsaicin evoked currents in (D). (E) Representative traces of currents evoked by focal application of 1 μM capsaicin (Caps, 2 s) and 100 μM NaHS (2 s) in control and after inhibition of TRPV1 receptors by capsazepine (10 μM); after washout and after inhibition of TRPA1 receptors by HC 030031 (50 μM). Notice that NaHS and capsaicin evoked currents were completely abolished by capsazepine. *p < 0.05 compared to the third application of capsaicin in control.