Table 1.
Gene Ontology analysis was performed using DAVID (https://david.ncifcrf.gov/) on H3K9ac-enriched genes in St Gallen molecular subtypes of breast cancer.
GO term name | Luminal A | Luminal B1 | Luminal B2 | TNBC | HER2-positive | |||||
---|---|---|---|---|---|---|---|---|---|---|
up | down | up | down | up | down | up | down | up | down | |
Regulation of metabolic process | 18 | 44 | 56 | 88 | 49 | 27 | 157 | 498 | 82 | 18 |
Regulation of cell process | 22 | 62 | 83 | 121 | 59 | 40 | 217 | 492 | 110 | 9 |
Cell proliferation | 10 | 24 | 32 | 15 | 10 | 40 | 88 | 28 | ||
Positive regulation of cell proliferation | 9 | 16 | 17 | 7 | 19 | |||||
Cell migration | 5 | 18 | 26 | 17 | 28 | 61 | 23 | |||
Negative regulation of cell death | 10 | 15 | 19 | 8 | 27 | 54 | 19 | |||
Negative regulation of programmed cell death | 10 | 14 | 17 | 8 | 27 | 52 | 18 | |||
Regulation of signaling | 22 | 38 | 38 | 75 | 156 | 40 | ||||
Cell-cell signaling | 6 | 17 | 34 | 38 | 13 | 16 | 43 | 32 | ||
Regulation of cell differentiation | 16 | 21 | 40 | 20 | 11 | 45 | 79 | 32 | 9 | |
Positive regulation of epithelial cell differentiation | 2 | 4 | 3 | 6 | 4 | |||||
Hormone-mediated signaling pathway | 3 | 6 | 4 | 8 | 4 |
The number of differentially modified genes is shown.