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. 2017 Jul 20;12:5163–5176. doi: 10.2147/IJN.S131089

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© 2017 Huang et al. This work is published and licensed by Dove Medical Press Limited

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Antitumor efficacy under NIR irradiation in vivo, and infrared thermal imaging.

Notes: (A) Infrared thermal images of the mice before (a–d) or after 10 min (e–h) of 808 nm NIR laser irradiation at 1.25 W cm⁻² and the color bar related the relative temperature values. The mice were injected systemically with NS (a, e), AuNCs (b, f), HPAuNCs (c, g), or HTPAuNCs (d, h). (B) Changes in the body weight of the mice with the time. (C) The tumor growth curves of eight groups. (D) Representative images of the tumors harvested from the mice after treatments. (E) Histomorphological assessments of tumor sections stained with hematoxylin–eosin after the treatment for 15 days. (B), (C), (D), and (E) grouping were as follows: (a) NS group; (b) NS + NIR group; (c) HTPAuNCs group; (d) HTPAuNCs + NIR group; (e) free DOX group; (f) DHPAuNCs group; (g) DHTPAuNCs group; (h) DHTPAuNCs + NIR group.

Abbreviations: AuNCs, gold nanocages; DHTPAuNCs, DOX-loaded, HA-grafted, and A54 peptide-targeted PEGylated AuNCs; DOX, doxorubicin; HPAuNCs, HA-grafted PEGylated AuNCs; HTPAuNCs, HA-grafted and A54 peptide-targeted PEGylated AuNCs; NIR, near-infrared irradiation; NS, normal saline.

Antitumor efficacy under NIR irradiation in vivo, and infrared thermal imaging.

Notes: (A) Infrared thermal images of the mice before (a–d) or after 10 min (e–h) of 808 nm NIR laser irradiation at 1.25 W cm⁻² and the color bar related the relative temperature values. The mice were injected systemically with NS (a, e), AuNCs (b, f), HPAuNCs (c, g), or HTPAuNCs (d, h). (B) Changes in the body weight of the mice with the time. (C) The tumor growth curves of eight groups. (D) Representative images of the tumors harvested from the mice after treatments. (E) Histomorphological assessments of tumor sections stained with hematoxylin–eosin after the treatment for 15 days. (B), (C), (D), and (E) grouping were as follows: (a) NS group; (b) NS + NIR group; (c) HTPAuNCs group; (d) HTPAuNCs + NIR group; (e) free DOX group; (f) DHPAuNCs group; (g) DHTPAuNCs group; (h) DHTPAuNCs + NIR group.

Abbreviations: AuNCs, gold nanocages; DHTPAuNCs, DOX-loaded, HA-grafted, and A54 peptide-targeted PEGylated AuNCs; DOX, doxorubicin; HPAuNCs, HA-grafted PEGylated AuNCs; HTPAuNCs, HA-grafted and A54 peptide-targeted PEGylated AuNCs; NIR, near-infrared irradiation; NS, normal saline.