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. 2005 Feb 16;102(9):3413–3418. doi: 10.1073/pnas.0409713102

Fig. 2.

Fig. 2.

Striatal proteasome activity after MPTP treatments. (a) Relative chymotrypsin-like, trypsin-like, and peptidyl-glutamyl-peptide hydrolyzing (PGPH) proteasome activities in mice exposed to a single (30 mg/kg) or four separate doses (20 mg/kg each) of MPTP (n = 5 mice at each time interval). Asterisks indicate statistically significant differences (P < 0.05) from baseline proteasome activity (single asterisk) or from both baseline proteasome activity and activity after single MPTP dose (double asterisk). (b) Delayed and prolonged inhibition of proteasome activity after continuous MPTP administration (1, 5, or 30 mg/kg MPTP daily) for the indicated time periods. Asterisks indicate statistically significant differences (P < 0.05) from baseline proteasome activity (single asterisk) or from both baseline proteasome activity and activity after lower MPTP doses (1 and 5 mg/kg, daily, double asterisk; n = 5 mice).