Fig. 5.
Effect of an α-synuclein deletion on MPTP toxicity. (a) Spontaneous horizontal activity and rearing of control and MPTP-treated wildt-ype and α-synuclein KO mice monitored in the open field test (30 mg of MPTP per kg daily for 28 days; n = 8). (b) Uptake of [14C]2-DG in littermate wild-type and α-synuclein KO mice that were continuously infused for 7 days with control or MPTP (30 mg/kg daily) solution. Pictures display false-color autoradiograms. (c) Proteasome activity in control and α-synuclein KO mice continuously infused with MPTP (30 mg per kg of body weight daily). Proteasome activities in the substantia nigra are depicted as percent of control (means ± SEMs) as a function of time after beginning of the infusions (five mice per group). In a and c, asterisks indicate statistically significantly different values (P < 0.05) from controls.