Table 2.

Summary of parameter values used in the present IR-based virus dynamic model

Symbol	Meaning	Unit	This study		IR modela
			A (H1N1)	A (H3N2)
		Variables
U(0)	Initial number of target cells		4×108		4×108
Is(0)	Initial sensitive infected cells		0		0
Ir(0)	Initial resistant infected cells		0		0
Vs(0)	Initial sensitive virus	TCID50 mL−1	7.7×10−3		7.7×10−3
Vr(0)	Initial resistant virus		0		0
X0	Initial immune response		0.34		0.34
		Parameters
dI	Infected cell death rate		0.5
dV	Virus death rate	d−1	8.1×10−2
P	Virus production rate	TCID50 d−1 mL−1	9×10−6	5×10−6	1.2×10−5
M	Mutation rate	Sensitive cell division−1	2.3×10−6	2.8×10−6	10−5
A	Antiviral efficacy		0.95	0.90	0.97
K	Unit conversion constant	d−1	1
b	Infection rate	mL d−1 TCID50−1	9.9×10−2
r	Immune response growth rate	d−1	0.85	0.70	1
c	Fitness cost of resistance		0.20	0.70	0.10
tr	Lag time of resistance virus	d	3	2	1.8

Notes:

^aOriginal data adapted from Handel et al¹⁹. Bold values denote values estimated by this study.

Abbreviations: IR, immune response; TCID, tissue culture infective dose.