Figure 4.

(A) Detailed map of plasmid pTP143 with genes assigned to COG categories and depicted in a color-coded manner. Rings from outside to inside represent positions of genomic islands (GI) (red); coding sequences (brown); GC content (black); GC skew (purple) and COG category assignment (multiple colors according to the color key) (B) GIs found on the megaplasmid pTP143 (linear view) have been highlighted. These regions contain hypothetical protein coding genes, some plasmid specific genes, a toxin-antitoxin system and repair genes. Most of the genes on the GIs were placed into COG category “L” (replication and repair).