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. 2017 Jul 26;7:6618. doi: 10.1038/s41598-017-07011-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FTI-277 ameliorated burn-induced decreases in mitochondrial oxygen consumption rate (OCR) in skeletal muscle. ADP- and FCCP-stimulated OCRs were significantly decreased by burn injury at 3 days post-burn, both of which were ameliorated by FTI-277 treatment (A–C). Similarly, complex I-, complex II-, and complex IV-dependent OCRs were significantly decreased at 3 days after burn injury, all of which were ameliorated by FTI-277 (D–G). The time points, in which ADP- (B), FCCP- (C), complex I- (E), complex II- (F), and complex IV- (G) dependent OCRs were evaluated, are indicated in A and C. ADP: adenosine diphosphate, Oligo: oligomycin, FCCP: carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone, Rote: rotenone, AA: antimycin A, Succ: succinate, Asc: ascorbate, TMPD: N, N, N9, N9-Tetramethylp-phenylenediamine. *P < 0.05, ***P < 0.001 vs. sham-burn groups, ^§P < 0.05, ^§§P < 0.01 vs. vehicle-treated burn group. n = 4 mice per group.