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. 2017 Jul 26;7:6618. doi: 10.1038/s41598-017-07011-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FTI-277 prevented burn-induced mitochondrial morphological changes in skeletal muscle. Enlarged mitochondria were observed in skeletal muscle at 3 days after burn injury, although enlarged mitochondria were not found in sham-burned mice. In addition, burn injury resulted in loss of cristae structure in some area of the mitochondria compared with sham-burn. FTI-277 prevented these morphological alterations induced by burn injury. On the other hand, FTI-277 did not affect the mitochondrial morphology in sham-burned mice (I–K). Arrows indicate the area with loss of cristae structure (G). (A–D): low magnification (6,800x), (E–H): high magnification (18,500x). scale bar: 500 nm. (A,E): sham-vehicle. (B,F): sham-FTI. (C,G): burn-vehicle. (D,H): burn-FTI.