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. 2017 Jul 26;7:6618. doi: 10.1038/s41598-017-07011-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FTI-277 inhibited burn-induced ER stress in skeletal muscle. Burn injury significantly increased phosphorylation of IRE1 (A,B) and Grp78 protein expression (A,D) compared with sham-burn. FTI-277 mitigated burn-induced increases in phosphorylation of IRE1 and protein expression of Grp78. IRE1 protein expression was not altered by burn injury or FTI-277. ***P < 0.001 vs. sham-burn groups, ^§§§P < 0.001 vs. vehicle-treated burn group. n = 6 mice per group.