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. 2017 Jul 26;7:6554. doi: 10.1038/s41598-017-06914-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GSK-J4 suppresses a specific subset of LPS-inducible genes in PM and BV-2 microglial cells. (A,B) A Venn diagram displaying the number of LPS-inducible genes that were suppressed or up-regulated with GSK-J4 treatment at 4-h after LPS stimulation in the PM and BV-2 microglial cells respectively. (C,D) Heat map representation depicting the positive regulators of inflammatory genes (cytokines, chemokines, IRGs, and undetected genes related to inflammation) that were selectively down-regulated by GSK-J4 at 4-h after LPS stimulation in PM (P ≤ 0.01, and log₂-fold change ≥1.5) and BV-2 microglial cells (P ≤ 0.01, and fold change ≥1.5) experiments, respectively. Heat maps were generated with the Multi Experiment Viewer (version 4.8) software. (E,F) UCSC Browser images representing the normalized RNA-seq read density in GSK-J4-down-regulated inflammatory genes at 4-h in the LPS-induced PM and BV-2 microglial cells compared with controls, respectively. (G,H) Transcript abundance (in read count) was evaluated using RNA-seq in GSK-J4-down-regulated inflammatory genes at 4-h in the LPS-induced PM and BV-2 microglial cells, respectively. (I) The area of overlap indicates the number of unique or shared GSK-J4 down-regulated genes after 4-h of LPS stimulation in PM and BV-2 microglial cells.