Table 4.

Leads to activation of inflammatory genes by identified TFs in response to GSK-J4 inhibited LPS induced inflammatory genes in PM and BV-2 microglial cells.

PM		BV-2
STAT1 predicted to be activated (61 genes) (p = 3.27 e-67)	IRF7 predicted to be activated (65 genes) (p = 4.16 e-83)	STAT1 predicted to be activated (29 genes) (p = 5.31 e-55)	IRF7 predicted to be activated (38 genes) (p = 2.09E-66)
CCL2, CCL3, CCL4, CCL5, CD14, CD40, CD86, CDKN1A, CH25H, CLIC5, CMPK2, CSF2, CXCL10, CXCL11, CXCL9, EDN1, FAM26F, FCER1G, GBP2, GBP3, GBP5, GBP6, HERC6, ICAM1, IFI16, IFI35, IFIT1, IFIT2, IFIT3, IFITM3, IL12B, IL15, IL15RA, IL6, ISG15, JAK2, KCTD12, LCN2, NOS2, PSMB10, PSMB8, PSMB9, PSME1, PSME2, RSAD2, SAMHD1, SLFN5, SOCS1, SOCS3, SP110, TAP1, TAPBPL, TNFSF10, TRAF2, TRAFD1, USP18, ACOD1, C2, CASP1, CASP4, CASP8	ADAR, CASP4, CCL5, CCL8, CD40, CD69, CD80, CMPK2, CXCL10, CXCL9, DAXX, DDX58, DHX58, FZD1, GBP3, GBP4, GBP5, HELZ2, IFI16, IFI35, IFI44, IFI44L, IFIH1, IFIT1, IFIT2, IFIT3, IFITM3, IL15, IL15RA, IL27, IRGM, ISG15, ISG20, JAK2, MX1, MX2, NAMPT, NMI, OAS2, OAS3, PARP12, PARP14, PELI1, PSMB10, PSMB8, PSMB9, PSME1, PSME2, RIPK1, RSAD2, RTP4, SAP30, SOCS1, TAP1, TAP2, TDRD7, TNFSF10, TPST1, TRAF1, TREX1, TRIM21, UBA7, USP18, XAF1, ZBP1,	CCL2, CCL5, CD274, CD40, CMPK2, CXCL10, GBP3, GBP5, IFIT1, IFIT2, IFIT3, IL15, ISG15, JAK2, MX1, OAS2, RSAD2, TAP1, TNFSF10, USP18, ACOD1, EIF2AK2, GBP2, HERC6, IL6, NOS2, SLFN5, SP110, TRAFD1	ADAR, CCL5, CD40, CD69, CMPK2, CXCL10, DDX58, DHX58, GBP3, GBP5, HELZ2, IFI44, IFIH1, IFIT1, IFIT2, IFIT3, IL15, IRGM, ISG15, ISG20, JAK2, MX1, MX2, OAS2, OAS3, PARP12, PARP14, PELI1, RSAD2, RTP4, TAP1, TNFSF10, TREX1, TRIM21, UBA7, USP18, XAF1, ZBP1