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| Mutation | Number of clones (%) | Contact residue |
|---|---|---|
| L248R | 1 (0.5) | X |
| Q252H | 1 (0.5) | |
| E255K | 4 (2.0) | |
| V299L | 1 (0.5) | X |
| T315I | 39 (19) | X |
| T315A | 60 (30) | X |
| F317V | 83 (41) | X |
| F317L | 10 (5.0) | X |
| F317I | 1 (0.5) | X |
| F317S | 1 (0.5) | X |
| Total: | 201 (100) |
The total number of recovered clones at 50 nM BMS-354825 with percentage of total indicated parenthetically. Mutations at drug-kinase contact residues are indicated.
