Table 3.
Renal tolerability of ibuprofen in children
| Year | Author | No. of patients | Disorder | Treatment | Adverse events/risk | Clinical outcome |
|---|---|---|---|---|---|---|
| 2000 | Gallego N [44] | 1 | Flu-like syndrome | Ibuprofen and aspirin | Tubulo-Interstitial-nephritis | Resolved |
| 2001 | Del Vecchio MT [85] | 1 | Febrile seizures | Ibuprofen and paracetamol | Acute renal failure | Resolved |
| 2001 | Wong W [41] | 1 | Diarrhoea, vomiting and fever | Paracetamol as initial treatment Ibuprofen 5 mg/kg/dose 3/day |
Acute renal failure | Resolved |
| 2004 | Moghal NE [86] | 1 | Flu-like syndrome | Ibuprofen (50 mg, 6 doses) | Mild cortical necrosis | Resolved |
| 2004 | Ulinski T [40] | 7 | Fever, diarrhoea and vomiting | Ibuprofen (n = 6): 11.5–32 mg/kg/day Ketoprofen (n = 1): 7.5 mg/kg |
Acute renal failure | Resolved |
| 2005 | Krause I [46] | 7 | Suicide attempt, fractures, headache | Ibuprofen (3 cases): 0.8–1.6 g | Acute renal failure | Resolved |
| 2007 | Leroy S [42] | – | Pain and fever | Ibuprofen: various doses | Acute renal failure | – |
| 2008 | Dixit MP [45] | 1 | Fever | Ibuprofen and aspirin | Acute renal failure | Resolved |
| 2013 | Misurac JM [43] | 1015 | – | Ibuprofen: 18 cases Ibuprofen + naproxen: 2 cases Ibuprofen + Ketorolac: 2 cases |
Acute kidney injury | – |
| 2014 | Yue Z [87] | 47,803 | – | Ibuprofen + paracetamol | Increased risk of acute renal failure | – |
| 2015 | Balestracci A [8] | 105 | Acute gastroenteritis | Ibuprofen | Acute kidney injury | – |