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. 2017 Jun 13;77(12):1281–1294. doi: 10.1007/s40265-017-0777-2

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Mechanisms of action of PGD₂ in allergic inflammation. The function of DP and CRTH2 receptors in inflammation can be regarded as antagonistic. In general, CRTH2 mediates the pro-inflammatory and pro-stimulatory effects of PDG₂, while DP may limit the effect of CRTH2 activation upon exposure to PGD₂. CRTH2 chemoattractant receptor-homologous molecule on T helper type 2 cells, DP D-prostanoid, FcεRI high-affinity receptor for immunoglobulin E, IL interleukin, PGD ₂ prostaglandin D₂. The figure was drawn by Łukasz Błażowski MD, PhD