| Several in vitro and in vivo studies in animal models of allergic inflammation confirmed the pivotal role of prostaglandin D2 (PGD2) and signaling via CRTH2 and D-prostanoid (DP) receptors, suggesting a possible role of the antagonism of those receptors in the management of allergic diseases in humans. |
| A number of CRTH2 and/or PGD2 receptor antagonists, including CRTH2 antagonist (OC000459), dual CRTH2 and thromboxane prostanoid receptor antagonist (ramatroban, BI671800), AMG 853, and AZ1981, have been investigated in asthma and allergic diseases. |
| The PGD2/CRTH2/DP1 pathway plays a key role in allergic inflammation and further studies with selective or combined antagonisms in well defined cohorts of patients are needed. |
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