Table 1.
MIC profiles of cerebrospinal fluid Klebsiella pneumoniae isolates from post-craniotomy and primary meningitis.
| MIC (μg/mL) of antibiotic compounds | Post-craniotomy meningitis (n = 13) | Primary meningitis (n = 20) | Total (n = 33) |
|---|---|---|---|
| Ampicillin | |||
| MIC50 | >16 | >16 | >16 |
| MIC90 | >16 | >16 | >16 |
| MIC range | >16 | >16 | >16 |
| Aztreonam | |||
| MIC50 | >16 | ≤1 | ≤1 |
| MIC90 | >16 | ≤1 | >16 |
| MIC range | ≤1–>16 | ≤1 | ≤1–>16 |
| Cefotaxime | |||
| MIC50 | >32 | ≤1 | ≤1 |
| MIC90 | >32 | ≤1 | >32 |
| MIC range | ≤1–>32 | ≤1–2 | ≤1–>32 |
| Ceftazidime | |||
| MIC50 | >16 | ≤1 | ≤1 |
| MIC90 | >16 | ≤1 | >16 |
| MIC range | ≤1–>16 | ≤1 | ≤1–>16 |
| Cefepime | |||
| MIC50 | 2 | ≤1 | ≤1 |
| MIC90 | 16 | ≤1 | 8 |
| MIC range | ≤1–>16 | ≤1 | ≤1–>16 |
| Piperacillin-tazobactam | |||
| MIC50 | >64 | ≤4 | ≤4 |
| MIC90 | >64 | 8 | >64 |
| MIC range | ≤4–>64 | ≤4–16 | ≤4–>64 |
| Meropenem | |||
| MIC50 | ≤0.25 | ≤0.25 | ≤0.25 |
| MIC90 | ≤0.25 | ≤0.25 | ≤0.25 |
| MIC range | ≤0.25 | ≤0.25 | ≤0.25 |
| Ciprofloxacin | |||
| MIC50 | 2 | ≤0.06 | ≤0.06 |
| MIC90 | >2 | 0.12 | 2 |
| MIC range | ≤0.06–>2 | ≤0.06–025 | ≤0.06–>2 |
| Colistin | |||
| MIC50 | 1 | 1 | 1 |
| MIC90 | 2 | 1 | 1 |
| MIC range | ≤0.5–2 | ≤0.5–1 | ≤0.5–2 |
| Tigecycline | |||
| MIC50 | 0.5 | 0.5 | 0.5 |
| MIC90 | 1 | 1 | 1 |
| MIC range | 0.5–1 | ≤0.25–2 | ≤0.25–2 |