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. 2017 Jul 26;7:6616. doi: 10.1038/s41598-017-06663-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Seed-to-target connectivity changes over time. The figure shows the seed-to-ROI connectivity found to be significantly different between groups. The red lines represent connections found to be stronger in presurgery patients (PS) compared to all other groups (lean controls, 1 month follow-up and 1 year follow-up). The yellow lines represent connections where a minor change occurred, as they were found to be stronger in presurgery patients compared with both lean controls (LS) and 1 month follow-up (1 m), but not to 1 year follow-up (1 y) nor between lean controls and 1 year follow-up. The green lines represent the connections where a change in connectivity was observed more slowly, as their connectivity was stronger in presurgery patients compared with lean controls and 1 year follow-up, but not compared with 1 month follow-up. All results were significant with a p < 0.05, corrected for multiple comparisons with a FDR approach. The image was generated with the CONN software used for the analysis.