Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition of retroviral, bacterial and human RNases H by hydroxylated tropolone derivatives
| Compound | IC50 HIV-1 RT (μM) | IC50 HIV-2 RT (μM) | IC50 E.c. Rnase H (μM) | IC50 Hu Rnase H (μM) |
|---|---|---|---|---|
| Tropolone | >100 | >100 | >100 | 3.0 |
| β-Thujaplicin | >100 | >100 | >100 | >100 |
| γ-Thujaplicin | >100 | >100 | >100 | 2.0 |
| Nootkatin | >100 | >100 | >100 | 25 |
| α-Thujaplicin | 50 | 33 | >100 | 12 |
| Manicol | 60 | 1.7 | 40 | 3.5 |
| β-Thujaplicinol | 0.21 | 0.77 | 50 | 5.7 |
IC50 values are the average of triplicate analyses.
