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. 2017 Jul 26;7:6632. doi: 10.1038/s41598-017-06698-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Chemical structures of SCH28080 and its derivatives. Chemical structures of SCH28080 and its derivatives used in this study are represented. Abbreviations for each compound are indicated. Dose-dependent inhibition of H⁺,K⁺-ATPase activity by these compounds in the presence of 10 mM KCl is shown in the graph. The half-inhibitory concentration of each compound at this K⁺ concentration (IC ₅₀) is indicated in parentheses.