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. 2017 Jul 26;7:6517. doi: 10.1038/s41598-017-06876-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlations between each MEG FC marker and cerebral amyloid deposition. The scatter plots show correlation between the PiB-DMNSUVR values (x axis) and PLV (y axis). The closed red circles and open blue circles indicate CN+ and CN− individuals, respectively. The brain images display the results of regression analysis between PiB-SUVR images and each MEG FC marker’s PLV. Brain areas that showed statistically significant correlations between regional PiB retention and each biomarker are visualized. The height threshold is p < 0.01 (FDR corrected), and the extent threshold is k = 200 voxels in all images. Note that the regression analyses for PCu-lIPL alpha showed no significant clusters with the above thresholds. FC: functional connectivity, DMNSUVR: mean standardized uptake value ratio (SUVR) within the default mode network (DMN). PLV: phase-locking value, CN+: cognitively normal PiB-positive, CN−: cognitively normal PiB-negative, FDR: false discovery rate, PCu: precuneus, lIPL; left inferior parietal lobule.