Table 1.

Demographics of the participants.

	CN+ (n = 13)	CN− (n = 32)	Statisticsp-value	Effect size φ/Cohen’s d
Sex (M: F)	7:6	13:19	0.42	0.12
Age (y)	71.85 ± 4.39	70.97 ± 4.25	0.54	0.21
Education (y)	12.38 ± 3.15	11.87 ± 2.63	0.58	0.18
MMSE	28.77 ± 1.09	28.88 ± 1.34	0.80	0.09
ADAS-Jcog	5.74 ± 2.19	5.66 ± 2.6	0.92	0.03
LM1	20.77 ± 7.25	20.84 ± 6.04	0.97	0.01
LM2	16.23 ± 6.85	16.97 ± 6.21	0.73	0.12
CDR	0	0	—	—
CDR SOB	0.04 ± 0.14	0.08 ± 0.18	0.49	0.24
GDS	2 ± 1.29	2.13 ± 1.68	0.81	0.08
APOEε4 (%)	4/13 (30.8%)	6/32 (18.8%)	0.38	0.13
PiB-mcSUVR *	1.41 ± 0.18	1.12 ± 0.05	<0.001	2.75
PiB-DMNSUVR *	1.52 ± 0.22	1.13 ± 0.06	<0.001	3.07
FDG-PET score	0.47 ± 0.18	0.50 ± 0.28	0.71	0.12
VSRAD z-score	0.54 ± 0.18	0.67 ± 0.41	0.31	0.34

Values are presented as mean ± SD. Statistical analyses were performed using the chi square test (sex, APOE) and Student’s t-test (others). The asterisks indicate statistically significant group differences. The effect sizes were computed as φ (sex, ApoE) or Cohen’s d (others).

MMSE: Mini-Mental State Examination, ADAS-Jcog: Alzheimer’s Disease Assessment Scale-Cognitive Component-Japanese version, LM1/LM2: Logical Memory I/II from the Wechsler Memory Scale–Revised (paragraph A and B), CDR: Clinical Dementia Rating, SOB: Sum of Boxes, GDS: Geriatric Depression Scale, APOEε4: positive for apolipoprotein Eε4, PiB-mcSUVR: mean cortical standardized uptake value ratio (SUVR) of PiB-PET, PiB-DMNSUVR: mean SUVR values within the 6 default mode network (DMN)-related regions of interest, FDG-PET score: a score that indicates the severity of the metabolic decrease in brain areas typically affected by Alzheimer’s disease, VSRAD z-score: the degree of gray matter atrophy of the medial temporal region using a z-score computed by Voxel-based Specific Regional Analysis System for Alzheimer’s Disease.