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. 2005 Mar 1;33(4):1257–1268. doi: 10.1093/nar/gki272

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Scheme 1 — The 71 bp sequence used to model a full turn of DNA based on the crystallographic structure of a nucleosome core particle (PDB code 1AOI) (50). The human genome consists of ∼3 × 10⁹ bp, two copies of which are contained in the nucleus of each somatic cell. The distance between the base pairs is ∼3.4 Å, leading to a total length of L = 2.04 m. The radius of gyration, including excluded volume effects, can be estimated (1) as $R_{g} \approx 1.28 \times \sqrt{2 a L / 3}$ , where a is the persistence length, taken here to be 500 Å, leading to a R_g value of 3.34 × 10⁻⁴ m.