Table 2.
In vitro cytotoxicity of CSPE fractions.
| CSPE fractions | WI38 IC50 (µg/ml) |
J774 IC50 (µg/ml) |
SI (IC50 WI38/IC50 J774) |
|---|---|---|---|
| CSPE1 | >20 | >20 | >1 |
| CSPE2 | >20 | >20 | >1 |
| CSPE3 | >20 | >20 | >1 |
| CSPE4 | >20 | 13.77 ± 1.26 | >1.4∗ |
| CSPE5 | >20 | 8.96 ± 1.09 | >2.2∗ |
| CSPE6 | >20 | >20 | >1 |
| CSPE7 | >20 | >20 | >1 |
| Camptothecin | 0.175 ± 0.029 | 0.011 ± 0.002 | 15∗∗∗ |
CSPE1–CSPE7: fractions of CSPE; camptothecin: positive control; results are expressed as mean ± standard error of the mean (SEM) from six determinations and activity differences between cell lines are statistically defined for each fraction with the Mann–Whitney or Wilcoxon signed-rank tests for comparison to the highest tested concentration (p < 0.05∗, p < 0.005∗∗∗).