Table 3.
Summary of individual exposure parameters for pyrimethamine and sulfadoxine during pregnancy and after delivery, stratified by site
| Country | Parameter | Pyrimethamine | Sulfadoxine | ||
|---|---|---|---|---|---|
| Pregnancy | After delivery | Pregnancy | After delivery | ||
| Mali | Sample size (%) | 18 | 18 (100) | 18 | 18 (100) |
| Cmax (mg/L) | 361 (337, 399) | 308 (286, 362) | 78.8 (75.4, 82.0) | 69.4 (65.7, 73.2) | |
| Tmax (h) | 3.30 (3.22, 3.34) | 3.18 (3.16, 3.25) | 8.72 (6.78, 11.6) | 9.64 (8.95, 11.3) | |
| AUCinf (mg·h/L) | 41.2 (37.0, 45.9) | 31.6 (23.9, 34.5) | 29659 (26958, 39623) | 64128 (54276, 83819) | |
| Cday7 (mg/L) | 81.9 (74.8, 99.5) | 62.8 (41.7, 68.5) | 40.5 (37.8, 44.4) | 44.6 (42.2, 49.6) | |
| Mozambique | Sample size (%) | 31 | 22 (71) | 31 | 22 (71) |
| Cmax (mg/L) | 589 (556, 646) | 670 (599, 736) | 87.5 (77.5, 97.9) | 92.0 (82.3, 98.6) | |
| Tmax (h) | 3.37 (3.35, 3.42) | 3.27 (3.18, 3.32) | 9.43 (9.23, 9.57) | 10.4 (10.3, 10.5) | |
| AUCinf (mg·h/L) | 83.2 (74.2, 94.7) | 77.8 (62.1, 93.3) | 43048 (34749, 52655) | 161419 (142185, 194938) | |
| Cday7 (mg/L) | 186 (167, 211) | 149 (121, 182) | 49.5 (43.6, 55.1) | 66.0 (58.8, 69.4) | |
| Sudan | Sample size (%) | 23 | 15 (65) | 23 | 15 (65) |
| Cmax (mg/L) | 443 (426, 509) | 436 (411, 464) | 78.3 (72.4, 87.3) | 75.2 (73.4, 80.3) | |
| Tmax (h) | 3.32 (3.28, 3.38) | 3.29 (3.26, 3.34) | 9.15 (9.11, 9.33) | 10.3 (10.3, 10.4) | |
| AUCinf (mg·h/L) | 54.6 (50.9, 65.3) | 56.6 (44.7, 61.5) | 30664 (27050, 39969) | 107707 (97106, 133040) | |
| Cday7 (mg/L) | 124 (98.7, 143) | 107 (91.2, 118) | 40.6 (37.0, 48.8) | 53.4 (51.5, 54.9) | |
| Zambia | Sample size (%) | 25 | 22 (88) | 25 | 22 (88) |
| Cmax (mg/L) | 236 (216, 246) | 216 (194, 239) | 59.7 (46.4, 67.1) | 47.4 (42.0, 52.4) | |
| Tmax (h) | 3.26 (3.25, 3.35) | 3.23 (3.16,3.29) | 8.88 (7.37, 10.4) | 9.86 (8.50, 17.5) | |
| AUCinf (mg·h/L) | 28.5 (23.3, 35.1) | 21.4 (16.9, 26.6) | 29037 (23293, 35084) | 35467 (29468, 42818) | |
| Cday7 (mg/L) | 58.4 (45.2, 65.3) | 39.3 (29.9, 54.4) | 31.4 (26.5, 36.9) | 29.5 (26.8, 33.9) | |
| Total | Sample size (%) | 97 | 77 (79) | 97 | 77 (79) |
| Cmax (mg/L) | 426 (304, 565) | 378 (264, 570) | 77.8 (67.1, 87.0) | 72.2 (53.7, 81.9) | |
| Tmax (h) | 3.33 (3.25, 3.38) | 3.25 (3.16, 3.30) | 9.29 (8.77, 9.59) | 10.3 (9.71, 10.6) | |
| AUCinf (mg·h/L) | 50.8 (34.3, 76.9) | 39.3 (23.7, 60.6) | 33068 (27010, 43638) | 88380 (45962, 140733) | |
| Cday7 (mg/L) | 107 (72.4, 162) | 72.9 (44.9, 120) | 41.8 (35.5, 49.9) | 49.4 (34.6, 58.7) | |
The values were generated using post‐hoc individual parameter values from the final model. Post‐hoc parameter values are expressed in median (interquartile range). AUCinf, area under whole‐blood concentration‐time curve extrapolated to infinity; Cday7, whole‐blood concentration on day 7; Cmax, maximum whole‐blood concentration; Tmax, time of maximum whole‐blood concentration.