Figure 1.

Key components of the pharmacokinetic/pharmacodynamic (PK/PD) model and scaling path. The human biomarker path is indicated by purple arrows, the rodent to human translation is indicated by thick gray arrows, and supporting quantitative relationships in rodents are depicted by gray arrows. Steps 1–4 include both empirical and mechanistic models. Target‐mechanism data were lacking in the melanin‐concentrating hormone receptor 1 program, and this is indicated by the gray color of that biomarker.